In most cases, this error occurs when users are trying to change settings in the Manage 3D Settings, or set the default graphics processor for a game on their computers. And a notification window will pop-up, showing NVIDIA Control Panel access denied, failed to apply selected settings to your system. Fix 5: Restore the Most Recent Working Version of Its FolderĪccording to the reports of NVIDIA users, sometimes they open NVIDIA Control Panel but cannot apply changes made for its configuration.Fix 3: Restart NVIDIA Display Driver Service.Fix 2: Run NVIDIA Control Panel as Administrator.